Endocrine Abstracts

Cardio-vascular disorders (CVD), ischemic heart disease (IHD) and myocardial infarction (MI) heading the line are the main cause of death among patients with diabetes mellitus (DM). DM has been proved to be an essential risk factor for IHD and MI to be instrumental in regarding all patients as belonging to the CVD high risk group. Dysfunction of adipocytes, insulin resistance, hyperinsulinemia, hyperglycemia and dyslipidemia seen in DM are the triggers for the cascade of hemod...

Diabetes mellitus with characteristic high blood serum glucose may cause various disorders, including damages to blood vessels. Both type 1 and type 2 DM increase the IHD risk by 4-6 times. The work was initiated to study parameters of lipid metabolism in patients with the IHD-combined type 1 and type 2 DM.Materials and Methods: We examined concentrations of total lipids, triglycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol...

The onset of diabetes mellitus caused by insulin deficiency and insulin resistance is simultaneous with the onset of disorders in lipid and carbohydrate metabolism. Phospholipids are subjected to major alterations in the lipid structures. The data on composition of phospholipids in diabetes mellitus are discordant. The work was initiated to study concentrations of phospholipids in blood of patients with type 1 and type 2 diabetes mellitus. 24 patients with type 1 DM (T1DM) and...

For quite a long period of time, diabetes mellitus (DM) has been considered as the carbohydrate metabolism disorder; to maintain blood glucose normal was believed to be the only mission of insulin. By now, findings from many studies have proved that DM is accompanied by the complex disorder of metabolism not only for carbohydrates, but also for lipids and proteins. Atherosclerotic injury of large vessels and ketoacidosis are known to be the main DM complications. The work was ...

2 type diabetes mellitus (2DM) determines high risk of cardio-vascular disorders and pathologies of cardio-vascular system, to name arterial hypertension, ischemic heart disease and hypercholesterolemia. In addition, prolonged insufficient DM compensation results in onset of macrovascular complications eventually causing adverse effects. UKPDS findings demonstrated that intense glycemia control significantly reduced the risk of microvascular diabetic complications, but produce...

Introduction: Metabolic disturbances at the Diabetes Mellitus (DM) leads to structural and functional abnormalities of the cell plasma membrane due to changes in the lipid content and composition, especially phospholipids. Plasmalogens are unique group of phospholipids with alcohol and ether bounds, presented in a few papers. We hypothesis their involvement into pathogenesis of DM.Material and methods: We studied the content of Plasmalogens in blood plas...

IntroductionNaKATPase is membrane bound enzyme, necessary for maintenance of the cell potential and volume, ion flow, neuronal signal transduction. Previous studies showed decreasing of its activity in patients with diabetes mellitus (DM). Mechanisms regulated enzymes activity in DM is not clear yet. We proposed that glycemia is a main regulator of NaKATPase activity in erythrocytes at the DM.Material and methods<p class="abste...

Introduction: Neurodegeneration is one of the most common condition accompanied Diabetes Mellitus, Parkinson’s and Alzheimer’s diseases. Although its mechanisms intensively studied for many years, some questions of pathogenesis remain unclear. The aim of the study was investigate the effects of thyroid hormones and some neurotransmitters on the cerebral cortex of rats with experimental neurodegeneration. Materials and methods: Series of experim...

For quite a long time, the brain has been considered as an insulin independent organ capable of utilizing glucose without participation of insulin. Today, insulin is thought to be not only a regulator of glucose transport and metabolism, but also as a modulator of some processes, including neuronal excitability, proliferation and differentiation of progenitor cells, synaptic plasticity, memory formation, secreting of neurotransmitters and apoptosis. The work was initiated to c...

Introduction: As were previously shown the erythrocytes glucose uptake is impaired in patients with the Diabetes Mellitus, obesity and polycystic ovarian syndrome due to insulin resistance. For further, study whether the erythrocytes glucose uptake will be impaired in rats with experimental metabolic syndrome were observed gradually.Material and methods: The 40 adult white male rats separated into 4 groups. In 10 rats diabetes were induced by injection o...